Clinical Observation of 29 Cases of Tonifying Kidney and Spleen, Detoxification of Throat Traditional Chinese Medicine in the Treatment of IgA Nephropathy

Purpose:To observe the clinical effect of tonifying kidney and spleen, detoxification of throat traditional Chinese medicine in the treatment of IgA nephropathy. Methods:60 patients with IgA nephropathy were randomly divided into treatment group and control group with 30 cases in each.The treatment group give tonifying kidney and spleen, detoxification of throat of Chinese herbal medicine, daily 1 agent.The control group was treated with Lotensin 10 mg, once daily orally.The course of treatment in the two groups are three months. Compared with the two groups before and after treatment, TCM syndrome score, 24 h urinary protein, urinary red blood cell count and adverse reaction. Results: In the treatment group, 1 cases loss. In the control group, 3 cases loss. Treatment group of TCM syndrome lumbar pain, sore throat, fatigue, edema, low sodium, xerostomia score decreased after treatment (P<0.05). Compared with before and after treatment,the treatment group with 24h urinary protein and urinary red blood cell count were significantly reduced (P<0.01).Control group after only 24h urinary protein decreased significantly (P<0.05), the difference in urinary red blood cell count no statistical significance (P>0.05). The two groups after treatment, the treatment group 24h urine protein and urine red blood cell count were significantly lower than the control group (P<0.05 or P<0.01).Two groups of patients before and after treatment of blood, routine, liver, kidney function,ECG,no abnormal changes. Conclusion: Tonifying kidney and spleen, detoxification of throat Chinese medicine can effectively improve patients with IgA nephropathy clinical symptoms, reduce 24h proteinuria and urinary red blood cell count,and is safe and effective.